The effects of heat and freeze-thaw cycling on naloxone stability
Source: Dulcie Lai, Amy Trinh Pham, Praveen P. Nekkar Rao and Michael A. Beazely, published in Harm Reduction Journal
January 1, 2019
The availability of take home naloxone (THN) was increased for Canadians in 2016, including access to kits via pharmacies. Unlike typical over-the-counter (OTC) and prescription drugs, THN kits may be stored in non-standard conditions, including in vehicles, backpacks, and out of doors. To evaluate whether these non-standard storage conditions affect stability, we investigated the impact of heat and freeze-thaw cycling on naloxone hydrochloride stability.